WebDec 12, 2024 · TIMP3 is frequently downregulated in PTC by promoter methylation. We have previously functionally demonstrated that TIMP3 exerts an oncosuppressor role in PTC: TIMP3 restoration in the PTC-derived NIM1 cell line affects in vitro migration, invasion and adhesive capability, while reduces tumor growth, angiogenesis and macrophage … WebFeb 6, 2024 · Furthermore, miR-375 binds to the macrophage CD36 receptor and is transferred to TAMs, where it directly binds and downregulates TNS3 and PXN, two migration-inhibitory proteins, ... mediate the pro-angiogenic switch in TAMs by downregulating the expression of the anti-angiogenic genes Pdcd4, Spry1, Timp3 Col4a2, …
Human Gene CD163 (ENST00000432237.3) from GENCODE V43
WebOct 28, 2011 · We observed a pronounced macrophage and T-cell influx upon the compound loss of TIMP3 and TNF, indicating a TNF-independent mechanism for their recruitment … Web3.2. MMP-14 and TIMP-3 Protein Expression in Macrophages and FCMs In Vitro. Consistent with the mRNA data, proinflammatory activation significantly elevated protein levels of … alberto ronconi
Overexpression of TIM-3 in Macrophages Aggravates …
WebJul 6, 2009 · We recently observed that TIMP3 deficiency is necessary to develop fatty streaks characterized by macrophage infiltrate using the insulin receptor heterozygous … WebMay 21, 2024 · These macrophages expressed prominent levels of monocarboxylate transporter-4 (MCT-4), which is specialized in the secretion of lactate from glycolytic … WebTIMP3, being an inhibitor of ADAM17 activity, inhibits TNF-α release and, consequently, MMP-9 expression. 74 In addition to its ability to regulating ECM remodeling, TIMP3 has also been shown to inhibit angiogenesis, through binding and blocking the vascular endothelial growth factor receptor (VEGFR)-2, 75 in order to stabilize newly formed … alberto roncone