Plectin protein
WebbPlectin was expressed in all adult and fetal tissues examined except leukocytes. Only a weak band was obtained from adult brain and thymus. Natsuga et al. (2010) determined that human fibroblasts express 2 different plectin isoforms: a 500-kD full-length protein and a 390-kD protein lacking the rod domain. Webb11 juli 2016 · RNA-binding proteins (RBPs) have essential roles in determining the fate of RNA from synthesis to decay and have been studied on a protein-by-protein basis, or computationally based on a number of ...
Plectin protein
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Webb15 aug. 2015 · Plectin, a versatile 500-kDa cytolinker protein, is essential for muscle fiber integrity and function. The most common disease caused by mutations in the human … WebbTo confirm the absence of plectin expression in mutant mice on the protein level, skin and muscle tissue homogenates prepared from mutant and wild-type mice were analyzed by immunoblotting using a rabbit anti-plectin antiserum (Figs. 1D and 2D) and monoclonal antibodies to plectin (data not shown), both immunoreactive with the rod domain of the …
Webb8 jan. 2024 · The PLEC gene (PLEC is the acronym for plectin) is a protein-coding gene located on 8q24.3. Until 2010, this gene locus was named Plectin 1 (symbol PLEC1 in humans), and the gene product was referred to as "hemidesmosomal protein 1" or "Plectin 1, intermediate filament binding 500kDa". These designations have been replaced by …
WebbPlectin is a highly preserved structural protein of the cytoskeleton expressed in several cell types, including skeletal muscle, postsynaptic membrane, and skin. Plectin deficiency … Webb30 aug. 2024 · Moreover, plectin is a scaffolding protein known to bind to the receptor for activated C kinase 1 (RACK1), thus modulating protein kinase C (PKC) signaling …
Webb9 feb. 2024 · Here, we show that plectin, a major intermediate filament-based cytolinker protein, orchestrates cortical cytoskeletal networks in epithelial sheets to support …
WebbThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human … kurma madinah ipohWebbPlectin/S10 domain; This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding. The actual alignment was detected with superfamily member pfam03501: javaweb表格代码Webb13 maj 2015 · The faster migration of rodless plectin keratinocytes is not due to altered biochemical properties because, like full-length plectin, rodless plectin is a dimeric protein. Our data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice. kurma kulambu seivathu eppadi in tamilWebbPlectin is an epidermal plakin protein, also found within the z-lines of striated muscle.48 Autosomal recessive mutations in PLEC cause EB simplex associated with muscular dystrophy, which manifests as relatively minor skin … javaweb菜鸟教程官网Webb21 dec. 2024 · Plectin, as a cytoskeleton-related protein, is involved in various physiological and pathological processes of many cell types. Studies have found that plectin affects cancer cell invasion and metastasis, but the exact mechanism is not fully understood. In this study, we aim to investigate the role of plectin in the migration of … kurma kesukaan nabiWebb12 apr. 2024 · Stability Test: The thermal stability is described by the loss rate. The loss rate was determinedby accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and noobvious degradation and precipitation were observed. The loss rate is less than 5% within theexpiration date under appropriate storage condition. [SEQUENCE] kur maksimal berapaWebb21 apr. 2024 · As such, therapeutic targeting of plectin, its protein interactors, and in particular, cancer-specific plectin (CSP), presents an attractive opportunity to impede carcinogenesis directly”. The article reports on plectin’s differential gene and protein expression in cancer, explores its mutational profile, and discusses the current … javaweb笔记老杜