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Web29 oct. 2016 · Mutatiile COMT vor duce la exces de dopamina, exces de SAM, exces de grupari metil – ceea ce are si un efect benefic, avand in vedere ca : BH4 necesar pentru sinteza dopaminei din tirozina va fi economisita. SAM va fi directionat catre alte procese consumatoare de grupari metil, ex. sinteza de ADN sau detoxifiere.
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