WebRenal medulla, hypertonicity Concentration of urine is made possible by generation of osmotic gradients in the renal medulla.This involves a counter-current process which pumps ions without water from the loops of Henle into the medullary interstitial fluid.When the filtrate passes down the collecting ducts lying parallel to the loops of Henle, water passes … WebThis low flow represents a compromise between the need to deliver nutrients to the medulla and the need to avoid washout of medullary hypertonicity. Second, and far more significant, the kidney uses a hairpin configuration, with the descending and ascending vasa recta both entering and leaving through the same region, thus creating an efficient …
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WebWe show that hypertonicity triggered an early, NFAT5-independent, genotoxic stress-like response with induction of p53, p21 and GADD45, downregulation of cyclins, and cell cycle arrest. Web6 jan. 2005 · Mammalian renal inner medullary cells are normally exposed to extremely high NaCl concentrations. Remarkably, under these normal conditions, the high NaCl … killer crossword clue dan word
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Web12 nov. 2012 · Only the long loops of Henle extend down into the renal medulla, and it is only these that play a role in producing the medullary hypertonicity. The mechanism that allows the loop of Henle to establish this large osmotic gradient between the tubular lumen and the medullary interstitium is known as ‘counter current multiplication’. Web25 aug. 2024 · Diuretics (natriuretics) are drugs that cause a net loss of Na+ and water in urine. The application or uses of diuretics in the management of hypertension has outstripped their use in edema. Classification of diuretics 1. High efficacy diuretics (Inhibitors of Na+- K+-2Cl¯ cotransport)- Sulphamoyl derivatives: (@BTF) Furosemide. Bumetanide. Web7 mrt. 2024 · NKCC2 activates the tonicity-responsive enhancer binding protein (TonEBP) transcription factor by creating medullary hypertonicity; Macula densa control of renin secretion and preglomerular resistance was studied with selective deletion of … killer croc gotham knight