WebOur ESC-GalNAc-conjugate delivery platform enables subcutaneous dosing of RNAi therapeutics with increased potency and durability, and a wide therapeutic index. Importantly, we have demonstrated that increased siRNA stability is the key to realizing these potency and durability improvements. In addition, our data suggest that further ... WebMay 9, 2024 · GalNAc conjugation subsequently emerged as the leading technology for the delivery of oligonucleotides, used for liver delivery by virtually every company in the RNA therapeutics space, including ...
Alnylam Pharmaceuticals Discontinues Revusiran Development
WebRVnGO is the first free person-to-person platform for RV rentals. This means that anyone with an RV, both professional RV rental fleets and individual RV owners can list their … WebAug 5, 2024 · Targeted delivery of oligonucleotides to liver hepatocytes using N-acetylgalactosamine (GalNAc) conjugates that bind to the asialoglycoprotein receptor has become a breakthrough approach in the therapeutic oligonucleotide field.This technology has led to the approval of givosiran for the treatment of acute hepatic porphyria, and … rsiv university of oxford
Sirnaomics Launches Phase I Clinical Trial for GalNAc Factor XI …
WebApr 26, 2024 · GalNAc technology is the mainstream nucleic acid delivery technology. GeneLeap Biotech has built a self-developed GalNAc delivery technology platform, and mastered advanced liver-targeted delivery technology in the field of nucleic acid drug therapy, which can effectively deliver nucleic acid drugs to liver lesions and bring benefits … WebSirnaomics’ proprietary delivery platforms for RNA-based therapeutics are the foundation of our product pipeline. Our polypeptide nanoparticle delivery platform (PNP) is primarily … WebApr 1, 2024 · The GalNAc delivery platform is mainly used for siRNA drugs. Three currently marketed siRNA drugs use the GalNAc delivery platform (Table 1). Tri-GalNAc binds to the hepatic binding protein or Ashwell–Morell receptor, resulting in rapid endocytosis. GalNAc-modified oligonucleotides can be specifically delivered to … rsj associates wilton