Cst plin2
WebGene target information for PLIN2 - perilipin 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. WebPLIN2 is an inherent perilipin protein, and its expression and phosphorylation are involved in lipolysis, lipophagy, lipid droplet fusion, and signal transduction. 49–52 PLIN2 activation-mediated LDs accumulation was observed in microglia activated by various inflammatory stimuli, which was closely related to the production of ROS and ...
Cst plin2
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WebFeb 15, 2016 · Perilipin2 (Plin2), also known as adipose differentiation-related protein (ADRP), or adipophilin, is a member of the PAT family involved in lipid droplet (LD) formation in the liver and peripheral ... WebSep 13, 2024 · Myelin uptake increases PLIN2 expression in macrophages in a PPARγ-dependent manner. Demyelinating lesions are characterized by the abundant presence of foamy macrophages loaded with cholesterol-containing LDs [].As PLIN2 is the main LD-associated protein on cholesterol-containing LDs and given its key role in LD biology [], …
WebAdipose differentiation-related protein, also known as perilipin 2, ADRP or adipophilin, is a protein which belongs from PAT family of cytoplasmic lipid droplet(CLD) binding protein. In humans it is encoded by the ADFP gene. This protein surrounds the lipid droplet along with phospholipids and are involved in assisting the storage of neutral lipids within the lipid … WebJan 19, 2024 · PLIN2 expression goes up when β cells are exposed to a lipid load or to …
WebSep 9, 2024 · A recent study showed that the generation of ROS can increase perilipin 2 (Plin2) expression in HepG2 cells. Some evidence has also demonstrated the association between Plin2 expression and renal tumors. However, the underlying mechanism of Plin2 in I/R-induced acute kidney injury (AKI) remains elusive. Here, using a mouse model of I/R … WebMar 29, 2024 · The PLIN2-intramuscular triglyceride association was reduced postexercise. PLIN2-PLIN5 proteins were all more abundant in women than in men (p = 0.037 and p < 0.0001, respectively), consistent with higher intramyocellular lipid content observed in female skeletal muscle. High PLIN2 protein level is associated with colorectal cancer.
WebResults The algorithm for NASH using PLIN2 mean florescence intensity (MFI) combined with waist circumference, triglyceride, alanine aminotransferase (ALT) and presence/absence of diabetes as covariates had an accuracy of 93% in the discovery cohort and of 92% in the validation cohort. Sensitivity and specificity were 95% and 90% in the …
WebPLIN2 is an inherent perilipin protein, and its expression and phosphorylation are involved in lipolysis, lipophagy, lipid droplet fusion, and signal transduction. 49–52 PLIN2 activation-mediated LDs accumulation was observed in microglia activated by various inflammatory stimuli, which was closely related to the production of ROS and ... インスタントラーメン 綴りWebDeng Y et al. Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics. Biochim Biophys Acta Mol Cell Biol Lipids 1866:158923 (2024). PubMed: 33713834; Correnti J et al. Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice. J Lipid Res 61:983-994 (2024). PubMed: 32398264 インスタントラーメン 焼きラーメン 味噌WebApr 28, 2024 · Moreover, PLIN2 knockout mice are resistant to diet-induced obesity, fatty liver disease and alcohol-induced steatosis, suggesting that PLIN2 is responsible for lipid accumulation, particularly in the liver [41, 42]. Taken together, these studies suggest that PLIN2 promotes LD formation and thereby protects TG from lipolysis. インスタントラーメン 親子WebNov 23, 2024 · Importantly, we found that the percentage of Plin2 + microglia was much higher in apoE4 mice (26%) compared to apoE2 (9%) and apoE3 (13%) mice (Fig. 6D). We next validated genes associated with lipid transport and metabolism and showed that Lpl and Apoc1 were altered in an apoE isoform-dependent manner. padiglione 15 careggiWebAug 23, 2024 · The lack of foamy microglia in TREM2 KO was confirmed by immunohistochemistry (IHC) using antibodies against perilipin 2 (PLIN2), a structural component of lipid droplets, and IBA1. In line with our ultrastructural analysis, the number of IBA1 + PLIN2 + cells increased in WT lesions at 21 and 62 dpi but not in TREM2 KO … padiglione 15WebFeb 8, 2024 · RDH/CG2064 interacts with the lipid droplet-resident protein Plin2 and the RDH/CG2064-Plin2 axis acts to reduce the overall level and lipid droplet localization of Bmm/ATGL lipase. This axis is important for larval survival under prolonged starvation. Thus, we discovered an RDH-Plin2 axis modulates lipid droplet size. padiglione 15 cattani parmaWebADFP may be a possible new marker for the identification of specialized differentiated … padiglione 14 torino